RP11-51O6.1 sponges miR-206 to accelerate colorectal cancer carcinogenesis and metastasis through upregulating YAP1

Abstract Long non-coding RNAs (lncRNAs) have been characterized by playing a crucial role in tumorigenesis. However, the detail biological function and clinical importance of lncRNAs colorectal cancer (CRC) are unclear attracted different levels in-depth research. In this context, we explored differentially expressed profiles six CRC tissues three adjacent non-tumor from RNA-sequencing (RNA-seq) study noted lncRNA, RP11-51O6.1, which is markedly overexpressed tissues, particularly aggressive cases. Impressively, an elevated RP11-51O6.1 level was highly correlated with poor prognosis patients. Functional analyses revealed that could promote cell proliferation vitro vivo. Furthermore, reported enhances migration invasion vitro. Mechanistic studies (Bioinformatics binding site analyses, Luciferase reporter, Ago2 immunoprecipitation, RNA pull-down, immunofluorescence colocalization, rescued assays western blotting) implicated regulate YAP1 expression competitively sponging miR-206 blocking its activity promoting progression. Conclusively, our findings identify novel RP11-51O6.1/miR-206/YAP1 regulatory axis participates progression development, suggesting exploitable biomarker appealing therapeutic target treating CRC.